Efficacy and Safety of Parathyroid Hormone Replacement Therapies for Chronic Hypoparathyroidism: A Systematic Review and Network Meta-Analysis
Supervisor Name
Mahmoud Alzaro
Supervisor Email
malzarro@staff.alquds.edu
University
Al-Quds University
Research field
Medical Sciences
Bio
Mahmoud Alzaro is a medical graduate from Al-Quds University in Palestine, with experience in clinical practice, pathology teaching, and medical research. He has successfully passed USMLE Step 1 and Step 2 CK. He has co-authored a peer-reviewed publication and contributed to research recognized at the Palestinian Undergraduate Research Conference. A graduate of the Palestinian Youth Leaders Program, he is committed to continuous learning, leadership, and contributing to his community through medicine and research.
Description
Chronic hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone secretion, leading to disturbances in calcium and phosphate homeostasis. Conventional treatment relies on calcium supplements and active vitamin D; however, these treatments do not replace the missing hormone and may not adequately address all aspects of the disease. Parathyroid hormone (PTH) replacement therapies have emerged as a potential alternative, making it important to evaluate their comparative efficacy and safety. This project aims to conduct a systematic review and network meta-analysis of randomized controlled trials to compare different PTH replacement therapies in adults with chronic hypoparathyroidism. The planned comparisons will include TransCon PTH (palopegteriparatide), recombinant human PTH(1–84), PTH(1–34), and conventional therapy or placebo, depending on the available trial evidence. Using both direct and indirect comparisons, the study will assess outcomes including serum calcium control, achievement of normocalcemia, urinary calcium excretion, reduction or discontinuation of active vitamin D and calcium supplementation, phosphate levels, treatment discontinuation, and adverse events. The review will follow established systematic review and network meta-analysis guidelines, with a structured literature search, independent assessment of study quality and risk of bias, and evaluation of the certainty of evidence. By synthesizing the available randomized evidence within a unified comparative framework, this project seeks to clarify the relative benefits and potential risks of available PTH replacement strategies, identify gaps in current evidence, and provide a foundation for more informed clinical decision-making and future research.