Diagnostic Yield and Clinical Impact of 7-Tesla MRI in Patients with Drug-Resistant Epilepsy and Negative 3-Tesla MRI

Supervisor Name

Zaher Nazzal

Supervisor Email

znazzal@najah.edu

University

An-Najah National University, faculty of Medicine and Health Sciences

Research field

Medical Sciences

Bio

Dr. Zaher Ahmad Nazzal is a Palestinian physician, academic, and researcher specializing in Community Medicine. Born on September 1, 1972, he earned his MD from Istanbul University’s Cerrahpaşa Medical Faculty in 1999 and completed his Arab Board certification in Community Medicine at Hamad Medical Corporation, Doha, Qatar, in 2009. With over two decades of experience, Dr. Nazzal has made substantial contributions to community health, medical education, and health systems research in Palestine and the broader Eastern Mediterranean region. Since 2011, Dr. Nazzal has served as an Associate Professor in the Department of Family and Community Medicine at An-Najah National University (ANNU). Over the years, he has held several key leadership roles, including Head of the Department of Family and Community Medicine, Head of the Research Unit, and Coordinator of Clinical Scientific Research at ANNU. He played an essential role in establishing the An-Najah Child Institute for Child Developmental Disorders and has participated impactful initiatives such as the HERA Project, which addresses healthcare responses to violence and abuse. Dr. Nazzal has taught research methods courses to medical and Master students for more than ten years, equipping generations of learners with essential skills in scientific inquiry and evidence-based practice. He has supervised over 150 research projects, many of which have contributed meaningfully to local and regional health knowledge. Dr. Nazzal’s research interests span a wide array of critical public health issues, including non-communicable diseases, antimicrobial resistance, maternal and child health, and pandemic response, particularly during the COVID-19 crisis. To date, he has published more than 100 articles in international peer-reviewed journals, significantly advancing understanding of health challenges in resource-limited and conflict-affected settings. He is an active member of several professional bodies, including the Palestinian Board Committee of Community Medicine and the Arab Board of Community Medicine. Fluent in Arabic, English, and Turkish, Dr. Nazzal is also proficient in statistical analysis software (e.g., SPSS) and reference management tools. ORCID Link/ID: https://orcid.org/0000-0002-2655-6109 SCOPUS ID: 36988148800 Google scholar ID: xjDQhMcAAAAJ ANNU Staff page: https://staff.najah.edu/en/profiles/3513

Description

Drug-resistant epilepsy (DRE) affects a substantial minority of people with epilepsy and carries significant morbidity and mortality. While resective surgery offers high rates of seizure freedom for focal DRE, success relies on accurate lesion localization. A major clinical challenge remains the subgroup of patients who test negative/non-lesional on optimized 3-Tesla (3T) MRI. Ultra-high-field 7-Tesla (7T) MRI provides higher signal-to-noise ratio and spatial resolution, potentially detecting subtle focal cortical dysplasia and structural abnormalities missed at 3T. This project aims to conduct a rigorous systematic review and meta-analysis following PRISMA-P 2015 guidelines and prospective PROSPERO registration to estimate the pooled additional diagnostic yield and clinical impact of structural 7T MRI in patients with DRE and negative 3T MRI. The synthesis will comprehensively evaluate primary diagnostic yield, changes in management/surgical plans, electroclinical concordance, histopathological confirmation, postoperative seizure outcomes, and scanning safety/feasibility.