Application of nanoparticle as antimicrobial agents against Palestinian pathogenic bacteria

Bacterial infections are a major cause of chronic infections and mortality worldwide. There is a great concerns in medical health science sectors about emerging new antibiotic resistance bacterial strains ,necessitating a search for alternative and innovative solution. Currently, The major groups of antibiotics that are in use targets either the cell wall synthesis, translational machinery, or DNA replication machinery. Unfortunately, bacterial resistance can develop against each of these modes of action. As an alternative way of using antibiotic is Nanoparticles that have emerged as a promising solution, as they are exhibiting unique properties by producing superoxide ions and hydroxyl radicals that efficiently kill bacteria. Metallic, polymeric, lipid, and carbon-based nanoparticles mostly exhibit antimicrobial actions by disrupting membranes, inhibiting enzymes, and producing different types of reactive oxygen species. Nanomaterials ( NPs) are materials that are very small with one dimension (1–100 nm) in the nanometer scale range or whose basic unit in the three-dimensional space is in this range. Current research showed that NPs in particular have a broad-spectrum antibacterial properties against both Gram-positive and Gram-negative bacteria. For example, ZnO NPs were found to inhibit Staphylococcus aureus, and Ag NPs exhibit concentration-dependent antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa. The current research will focuses on using nanoparticle and bio nanoparticles against local bacteria strain especially multidrug resistance bacteria including Methicillin resistance staphylococcus bacteria ( MRS) and E.coli